Oncotarget is an incorporative biomedical journal that provides information to scientists on scientific issues through in-depth review and creates informational unison between biomedical specialists, to enhance the application of basic and clinical scientific knowledge to combat diseases. It uses scientific indexes and archives. Oncortaget has achieved its objective of being first online publication journal to avail a consolidated issue to PubMed few days after publication.
Oncortaget is working on bettering the indexing process by publishing two issues a week. Scientists have assured the availability of all Oncortaget scientific publications on the following sites: PubMed, PubMed Central, ISI/Web of Science: Science Citation Index Expanded, Scopus, Biological Abstracts, BIOSIS Previews, Oncotarget.com, and EMBASE.
Oncortaget published an article on the role of nRNPC1C2 in dengue replication. It outlines the results of an experiment that involved in vitro method of dengue infection in a hepatocyte cell line and mediated knockdown of hnRNP C1C2 Mock. The knockdown cells produced during different periods of disease were examined for cell viability, proliferation, the percentage of dengue infection, amount of viral RNA and viral E and NS1.The final products were reviewed to determine the level of the infectious DENV and more
The human heterogeneous host and viral nuclear ribonucleoproteins (hnRNP) involved in dengue replication are C1C2 the host cellular proteins virus are many and facilitates a binding process of RNA enhancing replication of positive-strand RNA viruses, poliovirus, and hepatitis C virus. An interaction between hnRNPC1C2 and vimentin and viral NS1 in dengue-infected cells in DENV replication is unclear. The article also tried to highlight on the level at which dengue viruses are translated.
It indicated that the presence of the immunoprecipitated compound containing hnRNP c1C2 proteins the transfection resulted in the decreased level of hnRNPC1C2Mrna and protein though not lethal to the cells during the DENV infection. Reduction in level of hnRNP C1C2 indicated that the level of DEVN antigen-positive cells and the amount of DENV RNA, DENV and NS1 proteins despite the decrease, did not affect DENV translation In the reduction of DENV in the supernatant from the DENV infected cells following the knockdown of hnRNP C1C2 indicated that hnRNPC1C2 at the viral RNA synthesis process is involved in DENV replication.